A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter study.
Identifieur interne : 002C01 ( Main/Exploration ); précédent : 002C00; suivant : 002C02A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter study.
Auteurs : Alan L. Whone [Royaume-Uni] ; Dale L. Bailey ; Philippe Remy ; Nicola Pavese ; David J. BrooksSource :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 0161-5505 ] ; 2004.
English descriptors
- KwdEn :
- Algorithms, Antiparkinson Agents (therapeutic use), Canada, Dihydroxyphenylalanine (analogs & derivatives), Dopamine Agents (therapeutic use), France, Germany, Humans, Image Interpretation, Computer-Assisted (methods), Indoles (therapeutic use), Levodopa (therapeutic use), Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Tomography, Emission-Computed (methods), Treatment Outcome, United Kingdom.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents, Indoles, Levodopa.
- diagnostic imaging : Parkinson Disease.
- drug therapy : Parkinson Disease.
- methods : Image Interpretation, Computer-Assisted, Tomography, Emission-Computed.
- Algorithms, Canada, France, Germany, Humans, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, United Kingdom.
Abstract
We have recently completed a large 6-(18)F-fluoro-L-DOPA ((18)F-DOPA) PET study comparing rates of loss of dopamine terminal function in Parkinson's disease (PD) patients taking either the dopamine agonist ropinirole or L-DOPA. This trial involved a "distributed acquisition/centralized analysis" method, in which (18)F-DOPA images were acquired at 6 different PET centers around the world and then analyzed at a single site. To our knowledge, this is the first time such a centralized approach has been employed with (18)F-DOPA PET and this descriptive basic science article outlines the methods used.
PubMed: 15235059
Affiliations:
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Le document en format XML
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Whone</name><affiliation wicri:level="3"><nlm:affiliation>Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. alan.whone@csc.mrc.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bailey, Dale L" sort="Bailey, Dale L" uniqKey="Bailey D" first="Dale L" last="Bailey">Dale L. Bailey</name></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author><author><name sortKey="Pavese, Nicola" sort="Pavese, Nicola" uniqKey="Pavese N" first="Nicola" last="Pavese">Nicola Pavese</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. 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Whone</name><affiliation wicri:level="3"><nlm:affiliation>Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. alan.whone@csc.mrc.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bailey, Dale L" sort="Bailey, Dale L" uniqKey="Bailey D" first="Dale L" last="Bailey">Dale L. Bailey</name></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author><author><name sortKey="Pavese, Nicola" sort="Pavese, Nicola" uniqKey="Pavese N" first="Nicola" last="Pavese">Nicola Pavese</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name></author></analytic><series><title level="j">Journal of nuclear medicine : official publication, Society of Nuclear Medicine</title><idno type="ISSN">0161-5505</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Antiparkinson Agents (therapeutic use)</term><term>Canada</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dopamine Agents (therapeutic use)</term><term>France</term><term>Germany</term><term>Humans</term><term>Image Interpretation, Computer-Assisted (methods)</term><term>Indoles (therapeutic use)</term><term>Levodopa (therapeutic use)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (drug therapy)</term><term>Radiopharmaceuticals</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed (methods)</term><term>Treatment Outcome</term><term>United Kingdom</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agents</term><term>Indoles</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Interpretation, Computer-Assisted</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Canada</term><term>France</term><term>Germany</term><term>Humans</term><term>Radiopharmaceuticals</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Treatment Outcome</term><term>United Kingdom</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have recently completed a large 6-(18)F-fluoro-L-DOPA ((18)F-DOPA) PET study comparing rates of loss of dopamine terminal function in Parkinson's disease (PD) patients taking either the dopamine agonist ropinirole or L-DOPA. This trial involved a "distributed acquisition/centralized analysis" method, in which (18)F-DOPA images were acquired at 6 different PET centers around the world and then analyzed at a single site. To our knowledge, this is the first time such a centralized approach has been employed with (18)F-DOPA PET and this descriptive basic science article outlines the methods used.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Bailey, Dale L" sort="Bailey, Dale L" uniqKey="Bailey D" first="Dale L" last="Bailey">Dale L. Bailey</name><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name><name sortKey="Pavese, Nicola" sort="Pavese, Nicola" uniqKey="Pavese N" first="Nicola" last="Pavese">Nicola Pavese</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Whone, Alan L" sort="Whone, Alan L" uniqKey="Whone A" first="Alan L" last="Whone">Alan L. Whone</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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